A New Lipid Transfer Protein Homolog Identified as an IgE-Binding Antigen from Japanese Cedar Pollen
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- IBRAHIM Ahmed Ragaa Nour
- Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University
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- KAWAMOTO Seiji
- Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University
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- NISHIMURA Minori
- Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University
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- PAK Syunka
- Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University
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- AKI Tsunehiro
- Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University
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- DIAZ-PERALES Araceli
- Unidad de Bioquimica, Departamento de Biotecnologia, E.T.S. Ingenieros Agronomos, Universidad Politecnica
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- SALCEDO Gabriel
- Unidad de Bioquimica, Departamento de Biotecnologia, E.T.S. Ingenieros Agronomos, Universidad Politecnica
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- ASTURIAS Juan A.
- Research and Development Department, Bial-Aristegui
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- HAYASHI Takaharu
- Takanobashi Central Hospital
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- ONO Kazuhisa
- Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University
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Abstract
Japanese cedar (Cryptomeria japonica) pollen is a major cause of seasonal rhinitis and conjunctivitis in Japan, and an understanding of its full allergen repertoire is prerequisite for the development of future molecular diagnostics and immunotherapeutic strategies. Here we report the identification of a new C. japonica pollen IgE-binding antigen (CJP-8) homologous to lipid transfer proteins (LTPs), a class of plant cross-reactive allergens found in foods, latex, and pollen grains. The cjp-8 cDNA encodes a 165-amino acid polypeptide possessing the conserved eight cysteines characteristic of plant LTP family members. Escherichia coli-expressed recombinant CJP-8 (r-CJP-8) reacted with IgE antibody from Japanese cedar pollinosis patients at a 37.5% frequency (6/16).
Journal
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 74 (3), 504-509, 2010
Japan Society for Bioscience, Biotechnology, and Agrochemistry
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Details 詳細情報について
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- CRID
- 1390282681456789760
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- NII Article ID
- 10027552495
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- NII Book ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL BIB ID
- 10636182
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed