A New Lipid Transfer Protein Homolog Identified as an IgE-Binding Antigen from Japanese Cedar Pollen
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- IBRAHIM Ahmed Ragaa Nour
- Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University
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- KAWAMOTO Seiji
- Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University
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- NISHIMURA Minori
- Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University
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- PAK Syunka
- Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University
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- AKI Tsunehiro
- Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University
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- DIAZ-PERALES Araceli
- Unidad de Bioquimica, Departamento de Biotecnologia, E.T.S. Ingenieros Agronomos, Universidad Politecnica
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- SALCEDO Gabriel
- Unidad de Bioquimica, Departamento de Biotecnologia, E.T.S. Ingenieros Agronomos, Universidad Politecnica
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- ASTURIAS Juan A.
- Research and Development Department, Bial-Aristegui
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- HAYASHI Takaharu
- Takanobashi Central Hospital
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- ONO Kazuhisa
- Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University
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抄録
Japanese cedar (Cryptomeria japonica) pollen is a major cause of seasonal rhinitis and conjunctivitis in Japan, and an understanding of its full allergen repertoire is prerequisite for the development of future molecular diagnostics and immunotherapeutic strategies. Here we report the identification of a new C. japonica pollen IgE-binding antigen (CJP-8) homologous to lipid transfer proteins (LTPs), a class of plant cross-reactive allergens found in foods, latex, and pollen grains. The cjp-8 cDNA encodes a 165-amino acid polypeptide possessing the conserved eight cysteines characteristic of plant LTP family members. Escherichia coli-expressed recombinant CJP-8 (r-CJP-8) reacted with IgE antibody from Japanese cedar pollinosis patients at a 37.5% frequency (6/16).
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 74 (3), 504-509, 2010
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390282681456789760
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- NII論文ID
- 10027552495
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- NII書誌ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 10636182
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
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- 抄録ライセンスフラグ
- 使用不可