高分子の表面・界面　生体関連分野における機能発現Ｉ　　ポリ（Ｎ‐イソプロピルアクリルアミド）を組み込んだマイクロカプセルからの温度応答性放出制御

DOI Web Site 被引用文献1件 参考文献10件
  • KIDCHOB Tongjit
    Department of Material Chemistry, Graduate School of Engineering, Kyoto University
  • 木村 俊作
    京都大学大学院工学研究科材料化学専攻
  • 今西 幸男
    奈良先端科学技術大学院大学物質創成科学研究科

書誌事項

タイトル別名
  • Surface and Interface-New Functions of Biorelated Polymers I. Thermo-Responsive Microcapsules Using Poly(N-isopropylacrylamide).
  • ポリ N イソプロピルアクリルアミド オ クミコンダ マイクロカプセル カラ

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抄録

Two different types of thermo-responsive microcapsules were prepared by combining biodegradable polymer microcapsules and poly (N-isopropylacrylamide) (PNIPAAm). First, PNIPAAm was grafted on the surface of the polypeptide microcapsule by a new method of surface grafting. Dextran release from the microcapsule was faster below the lower critical solution temperature (LCST) of PNIPAAm than the rate above it. Then the temperature changed across the LCST, a reversible and thermo-responsive release from the microcapsule was observed. Notably, the transition of the release rate by changing the temperature occurred quickly in a narrow temperature range. Secondly, poly (L-lactic acid) (PLLA) microcapsules containing PNIPAAm gel were prepared. Internal cavities of PLLA microcapsules were filled partly or completely with PNIPAAm gel to obtain microcapsules for thermo-responsive drug release. The dextran release from the microcapsules showed a positively thermo-responsive release as the release was accelerated at the temperatures above the LCST, and nearly stopped below the LCST. The release rate of dextran was dependent on the amount of PNIPAAm gel loaded in the microcapsules as well as on the size of the internal cavities. The response rate of the microcapsules was also fast.

収録刊行物

  • 高分子論文集

    高分子論文集 55 (4), 192-199, 1998

    公益社団法人 高分子学会

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