交通流と翻訳過程

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タイトル別名
  • Traffic Flow and Translation Process
  • コウツウリュウ ト ホンヤク カテイ

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Messenger RNAs (mRNA), that code sequences of amino acids by using triplets of nucleotides (codons), are translated by multiple ribosomes. Usually more than one codon corresponds to an amino acid. The ribosome speed is known to dependent on the codon, thus there is a room to keep an amino acid sequence (protein) and change the ribosome speed. We model the ribosome traffic with codon-dependent rate estimated for E. coli and show that some wild type codon sequences can regulate “traffic jam” by placing slow codons at the begging of the mRNA. We discuss possible roles of slow codons in translation process.<br>

収録刊行物

  • 生物物理

    生物物理 53 (1), 015-019, 2013

    一般社団法人 日本生物物理学会

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