阻害剤開発のための2種のプロスタグランジン合成酵素の構造と機能

書誌事項

タイトル別名
  • Structure and Function of Two Prostaglandin (PG) Synthases for Drug Design
  • ソガイザイ カイハツ ノ タメ ノ 2シュ ノ プロスタグランジン ゴウセイ コウソ ノ コウゾウ ト キノウ

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抄録

The structural based drug-design (SBDD) is one of the useful methods for producing a novel medicine. We recently succeeded in X-ray crystallographic determination of two target molecules. One is human hematopoietic prostaglandin (PG) D synthase (H-PGDS) that produces PGD2 as an allergic mediator in mast cells and Th2 cells. The other is Trypanosoma brucei PGF synthase (TbPGFS), a member of the aldo-ketoreductase superfamily, catalyzes the NADPH-dependent reduction of PGH2 to PGF, whose overproduction during trypanosomiasis causes miscarriage in infected female subjects. In this report, we introduce the recent progress in the research of the high resolution structures of human H-PGDS and TbPGFS useful for SBDD.<br>

収録刊行物

  • 生物物理

    生物物理 47 (1), 036-043, 2007

    一般社団法人 日本生物物理学会

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