Effects of Nicotinic Acid and Tryptophan on Tyrosine Metabolism

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  • Nakashima Yoko
    Division of Adult Nutrition, The National Institute of Nutrition
  • Suzue Ryokuero
    Division of Adult Nutrition, The National Institute of Nutrition
  • Sanada Hiroo
    Division of Basic Nutrition, The National Institute of Nutrition
  • Utsuki Yoshio
    Division of Nutrition and Diseases, The National Institute of Nutrition

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Other Title
  • チロシン代謝に及ぼすニコチン酸とトリプトファンの影響
  • チロシン タイシャ ニ オヨボス ニコチンサン ト トリプトファン ノ エイキ

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In the nicotinic acid supplemented rats, the uptake of 14C-tyrosine into brain was lower than that of the nicotinic acid deficient rats at 2 hours after the administration of 14C-tyrosine. The causes of decrease in the uptake of 14C-tyrosine into the brain by the administration of nicotinic acid to the nicotinic acid deficient rats was described in this paper.<br>(1) The nicotinic acid deficient rats converted 14C-tyrosine more slowly to 14CO2 than the nicotinic acid supplemented rats. And the disappearance of 14C-tyrosine from serum was rapid by the administration of nicotinic acid to the nicotinic acid deficient rats.<br>(2) Nicotinic acid caused no change in tyrosine concentrations in the liver. Therefore, increased production of labeled CO2 by the administration of nicotinic acid did not affect the dilution of the labeled tyrosine by cold tyrosine.<br>(3) Tyrosine transaminase activity observed in the nicotinic acid deficient rats was lower than that of the nicotinic acid supplemented rats.<br>Therefore, the increased activity of tyrosine transaminase in liver and the increased turnover of 14C-tyrosine in the body after the administration of nicotinic acid to the nicotinic acid deficient rats decreased the uptake of 14C-tyrosine into the brain.

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