書誌事項
- タイトル別名
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- Effect of Hot-Spring Hydrotherapy on Lymphocyte Subsets Expressing β<sub>2</sub>-Adrenergic Receptors
- 短期温泉浴のβ2-アドレナリン受容体発現リンパ球サブセットへの影響
- タンキ オンセンヨク ノ ベータ 2 アドレナリン ジュヨウタイ ハツゲン リンパキュウ サブセット エ ノ エイキョウ
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We have previously reported that hot-spring hydrotherapy for a short duration can change hormone levels in the blood and quantitatively as well as qualitatively regulate leukocytes and their subpopulations. In this study, we examined the effect of hot-spring hydrotherapy on the lymphocytes expressing β2-adrenergic receptors (β2-ARs). We obtained peripheral blood from 9 healthy volunteers (age, 49.7±11.2 years) at the same sampling time before and after (the next day) hot-spring hydrotherapy, and measured the total and differential leukocyte counts and the levels of 3 catecholamines (adrenaline, noradrenaline, and dopamine). We also analyzed the β2-AR of lymphocyte subsets by combination with fluorescent monoclonal antibodies (CD3, CD4, CD 8, CD 19, and CD56) by using flow cytometry.<br> The number of granulocytes significantly decreased after hot-spring hydrotherapy (p < 0.05). The ratio of β2-AR+ CD4+ cells and β2-AR+ CD3+ cells was low, but that of β2-AR+ CD56+ cells and β2-AR+ CD8+ cells was high. The CD8+ cell and CD56+ cell counts tended to increase after hot-spring hydrotherapy, but no significant variation was found in the β2-AR+ cells of each subset. Adrenaline levels also significantly decreased after hot-spring hydrotherapy (p < 0.05). The rate of change in adrenaline levels before and after hot-spring hydrotherapy was highly correlated with the rate of change in the levels of CD56+, CD8+, and β2-AR+ CD56+ cells. Thus, we found a difference in thepercentage of β2-AR-expressing cells in the lymphocyte subsets. Therefore, it is possible that a short duration of hot-spring hydrotherapy decreased adrenaline levels and quantitatively influenced the natural killer cells and CD8+ cells, which express large amounts of β2-AR.
収録刊行物
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- 日本温泉気候物理医学会雑誌
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日本温泉気候物理医学会雑誌 73 (2), 101-108, 2010
一般社団法人 日本温泉気候物理医学会
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詳細情報 詳細情報について
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- CRID
- 1390282681546936192
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- NII論文ID
- 10026515862
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- NII書誌ID
- AN00186245
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- ISSN
- 18843697
- 00290343
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- NDL書誌ID
- 10591100
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可