Development of Leukocyte–mimetic Nanoparticles to Overcome the Blood–Brain Barrier in the Region of Ischemic Stroke

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  • Fukuta Tatsuya
    Department of Pharmaceutical Health Chemistry, Graduate School of Biomedical Sciences, Tokushima University
  • Kogure Kentaro
    Department of Pharmaceutical Health Chemistry, Graduate School of Biomedical Sciences, Tokushima University

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Other Title
  • 脳梗塞部位の血液脳関門突破を目指した 白血球模倣ナノ粒子の開発
  • ノウコウソク ブイ ノ ケツエキ ノウ カンモン トッパ オ メザシタ ハッケッキュウ モホウ ナノ リュウシ ノ カイハツ

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Description

Drug delivery with nano–sized liposomes has been demonstrated to be useful for the treatment of cerebral ischemia/reperfusion (I/R) injury by passing through the disintegrated blood–brain barrier (BBB), whereas liposomal entry was limited at early phase after I/R. Since leukocytes can pass through the BBB by their membrane protein functions under cerebral I/R conditions, imparting leukocyte–mimicking properties to liposomes may allow the liposomes to overcome the BBB in the I/R region. In this review, we will introduce our recent findings about development of leukocyte–mimetic nanoparticles to overcome endothelial barriers, including the BBB.

Journal

  • MEMBRANE

    MEMBRANE 44 (5), 217-221, 2019

    THE MEMBRANE SOCIETY OF JAPAN

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