Longitudinal investigation of <i>Propionibacterium acnes</i> burden and skin physiological function during menstruation in healthy women

DOI
  • Mukai Kanae
    Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University
  • Ogai Kazuhiro
    Wellness Promotion Science Center, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University
  • Kobayashi Masato
    Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University Wellness Promotion Science Center, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University
  • Ueda Terumi
    Faculty of Health Sciences, Department of Nursing, Komatsu University
  • Nakajima Yukari
    Department of Clinical Nursing, Graduate Course of Nursing Science, Division of Health Sciences, Graduate School of Medical Sciences, Kanazawa University
  • Nakatani Toshio
    Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University

Bibliographic Information

Other Title
  • 成人女性の性周期におけるプロピオニバクテリウムアクネス量と皮膚生理機能の変化に関する縦断的調査

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<p>Background: Monthly hormonal fluctuations during the menstrual cycle play a key role in the development of acne vulgaris in women. However, previous studies were questionnaire surveys and lacked objective data. Additionally, the physiological function of skin declines in acne vulgaris patients but little is known about these physiological changes during the menstrual cycle. Therefore, we aimed to clarify the longitudinal changes in the abundance of Propionibacterium acnes (P. acnes) in the skin of women during the menstrual cycle and the relationship between the abundance and skin physiological functions.</p><p>Materials and Methods: Six healthy women participated. Transepidermal water loss (TEWL), sebum secretion, stratum corneum (SC) hydration, and pH were measured, and skin bacteria (P. acnes) were collected from the left cheek every 2-3 days during the menstrual cycle.</p><p>Results: The relative abundance of P. acnes peaked after day 14 of the menstrual cycle and was rapidly decreased 2-3 days later. The relative abundance of P. acnes peaked on day 15 of the menstrual cycle in the subject who developed acne vulgaris, and the relative amount of Locus3 was simultaneously increased. The relative abundance of P. acnes was found to be correlated with TEWL (r=0.28, p<0.05) and SC hydration (r=-0.66, p<0.01).</p><p>Conclusion: Our findings show rapid changes in the number of P. acnes was occurred in the latter half of the menstrual cycle. Moreover, the physiological functions of skin were reduced when the number of P. acnes was increased. Therefore, improving the physiological function of skin may be necessary to prevent the development of acne vulgaris.</p>

Journal

  • Structure and Function

    Structure and Function 18 (1), 20-30, 2019

    Co-medical Research Society of Structure and Function

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