The role of sterile inflammation in ischemic stroke

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  • Nakamura Koutarou
    Stroke Renaissance Project, Tokyo Metropolitan Institute of Medical Science
  • Nakamura Akari
    Stroke Renaissance Project, Tokyo Metropolitan Institute of Medical Science
  • Ooboshi Hiroaki
    Department of Internal Medicine, Fukuoka Dental College Medical and Dental Hospital
  • Shichita Takashi
    Stroke Renaissance Project, Tokyo Metropolitan Institute of Medical Science Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University Japan Agency for Medical Research and Development (AMED)

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  • 脳梗塞における炎症の役割

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<p>The post-ischemic sterile inflammation will be a hopeful therapeutic target for ischemic stroke. Damage-associated molecular patterns (DAMPs) which are released from dying brain cells activate infiltrating immune cells through pattern recognition receptors. Inflammatory cytokines produced from activated macrophages/neutrophils induce T-cell-mediated secondary ischemic damages in the delayed phase of ischemic stroke. DAMPs are removed from ischemic brain through scavenger receptors, MSR1 which is highly expressed by repairing macrophages, for the resolution of cerebral post-ischemic inflammation. Thus, DAMPs are important regulators of sterile inflammation after ischemic stroke.</p>

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