Synergistic anti-candida activities of lactoferrin and the lactoperoxidase system
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- Nakano Manabu
- Food Ingredients & Technology Institute, R&D Division, Morinaga Milk Industry Co., Ltd.
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- Suzuki Motofumi
- Teikyo University Institute of Medical Mycology
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- Wakabayashi Hiroyuki
- Food Ingredients & Technology Institute, R&D Division, Morinaga Milk Industry Co., Ltd.
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- Hayama Kazumi
- Teikyo University Institute of Medical Mycology
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- Yamauchi Koji
- Food Ingredients & Technology Institute, R&D Division, Morinaga Milk Industry Co., Ltd.
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- Abe Fumiaki
- Food Ingredients & Technology Institute, R&D Division, Morinaga Milk Industry Co., Ltd.
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- Abe Shigeru
- Teikyo University Institute of Medical Mycology
書誌事項
- 公開日
- 2019-02-28
- 資源種別
- journal article
- DOI
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- 10.5582/ddt.2019.01010
- 公開者
- 特定非営利活動法人 バイオ＆ソーシャル・サイエンス推進国際研究交流会
この論文をさがす
説明
<p>Candida albicans is a commensal fungus in human mucosal surfaces, including the oral cavity. Lactoferrin (LF) and the lactoperoxidase (LPO) system, which are host protection components in exocrine secretions, each exhibit weak anti-candida activity. We herein examined the effects of the combination of LF and the LPO system on C. albicans. Morphological observations indicated that the combination of LF and the LPO system reduced the mycelial volume of C. albicans and changed the size and shape of cells more than each agent alone. The combination of LF and the LPO system also exerted strong inhibitory effects on the cellular metabolic activity and adhesive hyphal form of C. albicans. A checkerboard analysis revealed that the anti-candida activity of LF and the LPO system was synergistic. These results suggest that the combination of LF and the LPO system is useful for preventing candidiasis.</p>
収録刊行物
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- Drug Discoveries & Therapeutics
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Drug Discoveries & Therapeutics 13 (1), 28-33, 2019-02-28
特定非営利活動法人 バイオ＆ソーシャル・サイエンス推進国際研究交流会
