Study on genotoxicity of 3,3’-dichloro-4,4’-diaminodiphenylmethane and indus trial chemicals having similar chemical structure

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  • TOYOOKA Tatsushi
    Industrial Toxicology and Health Effects Research Group, National Institute of Occupational Safety and Health
  • QI Yonggang
    Industrial Toxicology and Health Effects Research Group, National Institute of Occupational Safety and Health Kitasato University Graduate School of Medical Sciences
  • WANG Rui-Sheng
    Industrial Toxicology and Health Effects Research Group, National Institute of Occupational Safety and Health
  • KODA Shigeki
    Industrial Toxicology and Health Effects Research Group, National Institute of Occupational Safety and Health

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Other Title
  • 3,3’-ジクロロ-4,4’-ジアミノジフェニルメタン及びその類似化学構造を有する産業化学物質のDNA損傷性に関する研究
  • 3,3'-ジクロロ-4,4'-ジアミノジフェニルメタン及びその類似化学構造を有する産業化学物質のDNA損傷性に関する研究 : γH2AXを指標に評価したDNA損傷強度の違い
  • 3,3'-ジクロロ-4,4'-ジアミノジフェニルメタン オヨビ ソノ ルイジ カガク コウゾウ オ ユウスル サンギョウ カガク ブッシツ ノ DNA ソンショウセイ ニ カンスル ケンキュウ : gH2AX オ シヒョウ ニ ヒョウカ シタ DNA ソンショウ キョウド ノ チガイ
  • － Strength of genotoxicity evaluated by γH2AX －
  • －γH2AXを指標に評価したDNA損傷強度の違い－

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Abstract

<p>3,3’-dichloro-4,4’-diaminodiphenylmethane (MOCA), an industrial chemical used as a curing agent for polyurethane pre-polymers, is known as a carcinogen that may cause occupational bladder cancer. Generation of DNA damage is a crucial first step in carcinogenesis, and it is clear from the previous studies that MOCA is genotoxic. On the other hand, it is still unknown whether MOCA produces a DNA double strand break, the most severe DNA damage closely related to carcinogenesis. In addition, there are no studies comparing genotoxicity between MOCA and the substances having similar chemical structures and using same application as MOCA. In this study, in order to grasp the hazard of chemical substances accurately, we carried out comparison of DNA damage properties among MOCA, 4,4’-diaminodiphenylmethane, 4,4’-diamino-3,3’-dimethyldiphenylmethane, and 4,4’-dihydroxydiphenylmethane using phosphorylated histone H2AX, having attracted attention in recent years as a biomarker of DNA doublestrand breaks. We found that all four tested substances induced γH2AX, and the induction was particularly strong in MOCA and 4,4’-dihydroxydiphenylmethane. The findings of this study are considered to provide important information for risk assessment of tested substances.</p>

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