Associations Between Metal Levels in Whole Blood and IgE Concentrations in Pregnant Women Based on Data From the Japan Environment and Children’s Study

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  • Tsuji Mayumi
    Department of Environmental Health, School of Medicine, University of Occupational and Environmental Health
  • Koriyama Chihaya
    Department of Epidemiology and Preventive Medicine, Kagoshima University Graduate School of Medical and Dental Sciences
  • Ishihara Yasuhiro
    Laboratory of Molecular Brain Science, Graduate School of Integrated Arts and Sciences, Hiroshima University
  • Yamamoto Megumi
    Department of Environment and Public Health, National Institute for Minamata Disease
  • Yamamoto-Hanada Kiwako
    Medical Support Center for Japan Environment and Children’s Study, National Center for Child Health and Development
  • Kanatani Kumiko
    Department of Health Informatics, Graduate School of Medicine and Public Health, Kyoto University
  • Bamai Yu Ait
    Department of Public Health, Hokkaido University Graduate School of Medicine, Sciences
  • Onishi Kazunari
    Center for Birth Cohort Studies, Interdisciplinary Graduate School of Medicine, University of Yamanashi
  • Senju Ayako
    Japan Environment and Children’s Study, UOEH Subunit Center, University of Occupational and Environmental Health Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health
  • Araki Shunsuke
    Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health
  • Shibata Eiji
    Department of Obstetrics and Gynecology, School of Medicine, University of Occupational and Environmental Health
  • Morokuma Seiichi
    Research Center for Environmental and Developmental Medical Sciences, Kyushu University
  • Sanefuji Masafumi
    Research Center for Environmental and Developmental Medical Sciences, Kyushu University
  • Kitazawa Hiroshi
    Medical Support Center for Japan Environment and Children’s Study, National Center for Child Health and Development
  • Saito Mayako
    Medical Support Center for Japan Environment and Children’s Study, National Center for Child Health and Development
  • Umezawa Masakazu
    Department of Materials Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science
  • Onoda Atsuto
    Division of Neonatology, Center for Maternal-Neonatal Care, Nagoya University Hospital Postdoctoral Fellow of Japan Society for the Promotion of Science
  • Kusuhara Koichi
    Japan Environment and Children’s Study, UOEH Subunit Center, University of Occupational and Environmental Health Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health
  • Tanaka Rie
    Department of Environmental Health, School of Medicine, University of Occupational and Environmental Health
  • Kawamoto Toshihiro
    Department of Environmental Health, School of Medicine, University of Occupational and Environmental Health
  • the Japan Environment & Children’s Study Group

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<p>Background: Metal exposures could possibly affect allergic responses in pregnant women, although no studies have yet shown a clear relationship between the two, and such exposures might also affect the development of allergic diseases in children.</p><p>Methods: We investigated the relationship between metal concentrations in whole blood and immunoglobulin E (IgE; total and specific) in 14,408 pregnant women who participated in the Japan Environment and Children’s Study. The subjects submitted self-administered questionnaires, and blood samples were collected from them twice, specifically, during the first trimester and again during the second/third trimester. Concentrations of the metals Cd, Pb, Hg, Se, and Mn, as well as serum total and allergen-specific IgEs for egg white, house dust-mites (HDM), Japanese cedar pollen (JCP), animal dander, and moth, were measured. Allergen-specific IgE(s) were divided based on concentrations <0.35 or ≥0.35 UA/mL, and the metal levels were divided into quartiles.</p><p>Results: Multivariable logistic regression analysis showed that there was a significant negative correlation between HDM- and animal dander-specific IgEs and Hg and Mn concentrations. Conversely, there was a significant positive relationship between JCP-specific IgE and Hg and Se concentrations.</p><p>Conclusions: Metal exposures may be related to both increases and decreases in allergen-specific IgEs in pregnant women.</p>

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