Associations Between Metal Levels in Whole Blood and IgE Concentrations in Pregnant Women Based on Data From the Japan Environment and Children’s Study
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- Tsuji Mayumi
- Department of Environmental Health, School of Medicine, University of Occupational and Environmental Health
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- Koriyama Chihaya
- Department of Epidemiology and Preventive Medicine, Kagoshima University Graduate School of Medical and Dental Sciences
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- Ishihara Yasuhiro
- Laboratory of Molecular Brain Science, Graduate School of Integrated Arts and Sciences, Hiroshima University
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- Yamamoto Megumi
- Department of Environment and Public Health, National Institute for Minamata Disease
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- Yamamoto-Hanada Kiwako
- Medical Support Center for Japan Environment and Children’s Study, National Center for Child Health and Development
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- Kanatani Kumiko
- Department of Health Informatics, Graduate School of Medicine and Public Health, Kyoto University
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- Bamai Yu Ait
- Department of Public Health, Hokkaido University Graduate School of Medicine, Sciences
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- Onishi Kazunari
- Center for Birth Cohort Studies, Interdisciplinary Graduate School of Medicine, University of Yamanashi
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- Senju Ayako
- Japan Environment and Children’s Study, UOEH Subunit Center, University of Occupational and Environmental Health Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health
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- Araki Shunsuke
- Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health
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- Shibata Eiji
- Department of Obstetrics and Gynecology, School of Medicine, University of Occupational and Environmental Health
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- Morokuma Seiichi
- Research Center for Environmental and Developmental Medical Sciences, Kyushu University
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- Sanefuji Masafumi
- Research Center for Environmental and Developmental Medical Sciences, Kyushu University
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- Kitazawa Hiroshi
- Medical Support Center for Japan Environment and Children’s Study, National Center for Child Health and Development
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- Saito Mayako
- Medical Support Center for Japan Environment and Children’s Study, National Center for Child Health and Development
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- Umezawa Masakazu
- Department of Materials Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science
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- Onoda Atsuto
- Division of Neonatology, Center for Maternal-Neonatal Care, Nagoya University Hospital Postdoctoral Fellow of Japan Society for the Promotion of Science
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- Kusuhara Koichi
- Japan Environment and Children’s Study, UOEH Subunit Center, University of Occupational and Environmental Health Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health
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- Tanaka Rie
- Department of Environmental Health, School of Medicine, University of Occupational and Environmental Health
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- Kawamoto Toshihiro
- Department of Environmental Health, School of Medicine, University of Occupational and Environmental Health
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説明
<p>Background: Metal exposures could possibly affect allergic responses in pregnant women, although no studies have yet shown a clear relationship between the two, and such exposures might also affect the development of allergic diseases in children.</p><p>Methods: We investigated the relationship between metal concentrations in whole blood and immunoglobulin E (IgE; total and specific) in 14,408 pregnant women who participated in the Japan Environment and Children’s Study. The subjects submitted self-administered questionnaires, and blood samples were collected from them twice, specifically, during the first trimester and again during the second/third trimester. Concentrations of the metals Cd, Pb, Hg, Se, and Mn, as well as serum total and allergen-specific IgEs for egg white, house dust-mites (HDM), Japanese cedar pollen (JCP), animal dander, and moth, were measured. Allergen-specific IgE(s) were divided based on concentrations <0.35 or ≥0.35 UA/mL, and the metal levels were divided into quartiles.</p><p>Results: Multivariable logistic regression analysis showed that there was a significant negative correlation between HDM- and animal dander-specific IgEs and Hg and Mn concentrations. Conversely, there was a significant positive relationship between JCP-specific IgE and Hg and Se concentrations.</p><p>Conclusions: Metal exposures may be related to both increases and decreases in allergen-specific IgEs in pregnant women.</p>
収録刊行物
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- Ｊｏｕｒｎａｌ ｏｆ Ｅｐｉｄｅｍｉｏｌｏｇｙ
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Ｊｏｕｒｎａｌ ｏｆ Ｅｐｉｄｅｍｉｏｌｏｇｙ 29 (12), 478-486, 2019-12-05
日本疫学会