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- 金沢 貴憲
- 日本大学薬学部薬剤学
書誌事項
- タイトル別名
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- Development of non-invasive drug and biomedicine delivery technologies based on the physiological nose-to-brain routes
抄録
<p>The blood-brain barrier (BBB) poses a major challenge to the drug development efforts targeting brain/central nervous system (CNS) diseases, since it limits the distribution of systemically administered therapeutics to the brain/CNS. Therefore, the development of effective strategies for enhancing drug delivery to the brain has been a topic of great interest in both clinical and pharmaceutical fields. Intranasal administration has been noted as a method of non-invasive delivery of a drug to the brain/CNS by bypassing the BBB via the nose-to-brain route. This "nose-to-brain" delivery system has the potential to be highly versatile, and a combination of this system with the new drug and biomedicine, which is thought to show promise in the treatment of CNS diseases. In addition, nano-sized drug carriers can improve nose-to-brain delivery.</p><p>In this seminar, we introduce overview of nose-to-brain delivery and our developed cell penetrating Tat peptide-modified block copolymer micelles (PEG-PCL-Peptide) for improvement of mucosal permeability and nose-to-brain transport efficiency. </p>
収録刊行物
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- 日本薬理学会年会要旨集
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日本薬理学会年会要旨集 93 (0), 2-MS3-, 2020
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390283659859274752
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- NII論文ID
- 130007811537
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- ISSN
- 24354953
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可