書誌事項
- タイトル別名
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- Blockade of endothelin ET<sub>B</sub> receptor ameliorates brain edema by regulation of astrocyte-derived factors after traumatic brain injury in mice
抄録
<p>Brain edema is a critical condition resulted from blood-brain barrier (BBB) disruption after traumatic brain injury (TBI). Several astrocyte-derived factors are involved in BBB function. We previously confirmed the involvements of endothelin ETB receptor for BBB disruption. In this study, the effects of BQ788, an ETB receptor antagonist on brain edema and astrocyte-derived factors were examined. As a model of TBI, fluid percussion injury (FPI) was performed on mouse cerebrum. BBB disruption and brain edema were evaluated by Evans blue extravasation and brain water content, respectively. Expressions of astrocyte-derived factors were confirmed by Real-time PCR and immunohistochemistry. To confirm therapeutic efficiencies, intraventricular (i.c.v., 15 nmol/day) or intravenous (i.v., 5 mg/kg/day) administration of BQ788 were performed from 2 to 5 days after FPI. BQ788 ameliorated FPI-induced BBB disruption and brain edema but not affected blood pressure. ETB receptors were mainly distributed in astrocytes and BQ788 appropriately controlled expressions of several astrocyte-derived factors after FPI. Thus, blockade of ETB receptor is expected to be a novel therapeutic strategy for brain edema.</p>
収録刊行物
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- 日本薬理学会年会要旨集
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日本薬理学会年会要旨集 92 (0), 2-YIA-20-, 2019
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390283659860699264
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- NII論文ID
- 130007813167
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- ISSN
- 24354953
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可