Pharmacotherapy with amantadine and mexiletine was effective for phantom limb pain that developed after lower-limb amputation surgery

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  • FUJITA Masahide
    Department of Anesthesiology, Tsukuba University Hospital
  • INOMATA Shinichi
    Department of Anesthesiology, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba
  • TAKAO Ikuko
    Department of Anesthesiology, Tsukuba University Hospital
  • YAHAGI Musashi
    Department of Anesthesiology, Tsukuba University Hospital
  • KUMADA Yuki
    Department of Anesthesiology, Tsukuba University Hospital
  • TANAKA Makoto
    Department of Anesthesiology, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba

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Other Title
  • 薬物療法により症状の緩和が得られた股関節切断術後の幻肢痛の1例
  • 症例 薬物療法により症状の緩和が得られた股関節切断術後の幻肢痛の1例
  • ショウレイ ヤクブツ リョウホウ ニ ヨリ ショウジョウ ノ カンワ ガ エラレタ コカンセツ セツダン ジュツゴ ノ ゲンシツウ ノ 1レイ

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Abstract

<p>A 59-year-old Japanese woman suffered from necrotizing fasciitis in her right lower limb and underwent amputation of the limb at the hip joint. Immediately after the surgery, she experienced phantom sensations in the right lower limb, dysesthesia, and stump pain. We started pregabalin treatment (oral 150 mg/day) on postoperative day 3, but the phantom limb sensation and dysesthesia did not improve. When amantadine (oral 200 mg/day) was started on postoperative day 8, her symptoms gradually improved. Mexiletine (oral 200 mg/day) was started on postoperative day 31, and symptoms further alleviated. In the combination therapy with pregabalin (oral 450 mg/day), amantadine (oral 450 mg/day), and mexiletine (oral 300 mg/day) to treat phantom limb pain, amantadine was particularly effective. The patient's positive outcome suggests that amantadine is an effective treatment option for phantom limb pain and phantom limb sensations after limb amputation.</p>

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