Magnetic nanoparticle detection in lymph nodes of breast cancer patients for cancer diagnosis

DOI

Bibliographic Information

Other Title
  • がん診断における乳がんセンチネルリンパ節内の磁気ナノ粒子の検出

Abstract

<p>The quantitative detection of the magnetic nanoparticles (MNPs) in sentinel lymph nodes (SLNs) can help to diagnose cancer metastasis for breast cancer patients because the SLN (i.e., 1st SLN) containing the largest amount of the MNPs has the metastasis with the highest probability. In this study, we have optimized the frequency of alternating current (AC) magnetic fields under the application of direct current (DC) magnetic fields to achieve the highly-sensitive detection, and demonstrated the intraoperative detection of the MNPs accumulated into the SLNs to reduce the injection amount. Considering the noise signal and hysteresis loss, AC fields with 2-5 kHz was effective for the detection. The clinical trials with breast cancer patients, for the MNP detection using a developed device, revealed that the MNP amount of 1st SLN was ~40 ug. We will pursue the further detailed magnetic characteristics of the device and the MNPs for biomedical applications.</p>

Journal

Details 詳細情報について

  • CRID
    1390285300180902784
  • NII Article ID
    130007884938
  • DOI
    10.11239/jsmbe.annual58.284
  • ISSN
    18814379
    1347443X
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

Report a problem

Back to top