Development of Receptor-sensitive Near-infrared Absorbing azaBODIPY Dye for Glucose Sensors

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  • MIZUKAMI Yasuto
    Graduate School of Science and Engineering, University of Toyama
  • TOHDA Koji
    Faculty of Engineering, Academic Assembly, University of Toyama
  • KANNO Akira
    Faculty of Engineering, Academic Assembly, University of Toyama

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Other Title
  • グルコースセンサ用レセプター感受性近赤外吸収azaBODIPY色素の開発
  • グルコースセンサヨウ レセプター カンジュセイ キンセキガイ キュウシュウ azaBODIPY シキソ ノ カイハツ

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Abstract

<p>With the aim of developing a subcutaneously implantable optical sugar sensor that can continuously measure blood glucose levels, we have developed a novel dye that changes the absorption spectrum in the near-infrared wavelength region by forming a complex with glucose receptors. As a result of synthesizing six types of azaBODIPY dyes having a catechol moiety, it was found that the absorption spectrum of each dye changes due to the complex formation with phenylboronic acid (PBA), which is a model compound of sugar receptors. Among the receptor-sensitive dyes we synthesized, thienyl-azaBODIPY, in which three thienyl groups were introduced into the molecule, showed the maximum absorption wavelength (732 nm) on the longest wavelength side. It was found that when glucose was added to a solution containing thienyl-azaBODIPY and the glucose receptor bisbenzoboroxol (bisBB), the absorbance in the near-infrared wavelength region changed significantly depending on the glucose concentration.</p>

Journal

  • BUNSEKI KAGAKU

    BUNSEKI KAGAKU 70 (3), 159-164, 2021-03-05

    The Japan Society for Analytical Chemistry

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