生体内バリアを突破する核酸デリバリー

書誌事項

タイトル別名
  • Nucleic Acid Delivery across Biological Barriers
  • Symposium Review 生体内バリアを突破する核酸デリバリー
  • Symposium Review セイタイナイ バリア オ トッパ スル カクサン デリバリー

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抄録

<p>One of the current critical issues in nucleic acid delivery is the efficient mRNA delivery into target cells, directed toward clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) genome editing. To this end, we have developed a variety of cationic polyaspartamide derivatives with varying side chain structures because they can form nanocomplexes, termed polyplexes, with mRNA through electrostatic interactions. Interestingly, the delivery functions were highly affected by the chemical structures of the polyaspartamide side chains. Therefore, we review our previous research and provide a rationale for designing polypeptides for mRNA delivery.</p>

収録刊行物

  • 薬学雑誌

    薬学雑誌 141 (5), 635-639, 2021-05-01

    公益社団法人 日本薬学会

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