カネミ油症患者のダイオキシン類の半減期と芳香族炭化水素受容体(AhR)のSNPの関係

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  • Relationships between Half-Lives of Dioxins and SNPs in AhR among Yusho Patients
  • カネミユショウ カンジャ ノ ダイオキシンルイ ノ ハンゲンキ ト ホウコウゾク タンカスイソ ジュヨウタイ(AhR)ノ SNP ノ カンケイ

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Half-lives of blood levels of 2,3,4,7,8-Pentachlorodibenzofuran (PeCDF) are varied in Yusho patients. The objective was to evaluate a relationship between half-lives of PeCDF levels and types of SNP rs10249788 of aryl hydrocarbon receptor (AHR) gene in 93 Yusho patients. Based on physical symptoms, age, sex, body mass index and other factors, we set up suitable calculation formulas to fit the actual PeCDF levels thorough rates of change in PeCDF.We found that patients with C/T SNP had longer half lives than patients with C/C and T/T SNPs. Patients with T/T SNP are known to express higher amount of AHR mRNAs. However, detailed analysis could not be carried out in T/T group due to a limited number of patients (n=11). Further research is warranted to determine the cause of the longer half-lives in C/T patients.

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