A Probable Case of Burn-out NASH Caused by Panhypopituitarism Secondary to Craniopharyngioma

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  • Terawaki Yuichi
    Department of Endocrinology and Diabetes Mellitus, School of Medicine, Fukuoka University
  • Murase Kunitaka
    Department of Endocrinology and Diabetes Mellitus, School of Medicine, Fukuoka University
  • Motonaga Ryoko
    Department of Endocrinology and Diabetes Mellitus, School of Medicine, Fukuoka University
  • Tanabe Makito
    Department of Endocrinology and Diabetes Mellitus, School of Medicine, Fukuoka University
  • Nomiyama Takashi
    Department of Endocrinology and Diabetes Mellitus, School of Medicine, Fukuoka University
  • Shakado Satoshi
    Department of Gastroenterology and Medicine, School of Medicine, Fukuoka University
  • Mizoguchi Mikiro
    Department of Pathology, Faculty of Medicine, Fukuoka University
  • Sakisaka Shotaro
    Department of Gastroenterology and Medicine, School of Medicine, Fukuoka University
  • Yanase Toshihiko
    Department of Endocrinology and Diabetes Mellitus, School of Medicine, Fukuoka University

Bibliographic Information

Other Title
  • 頭蓋咽頭腫の長期治療経過に伴う汎下垂体機能低下症により肝硬変症をきたしたと考えられる一例
  • Case Report : A Probable Case of Burn-out NASH Caused by Panhypopituitarism Secondary to Craniopharyngioma

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Description

A 38-year-old man diagnosed with craniopharyngioma at 8 years old underwent repeated surgery and radiation therapy. Complications included panhypopituitarism including growth hormone deficiency and hypogonadism at 13 years old. At 26 years of age, a slight fatty liver was found, which finally developed into liver cirrhosis (LC) at 35 years old. Viral infection or other etiologies causing LC were negative on serum examinations. Liver biopsy suggested a possibility of burn-out non-alcoholic steatohepatitis. This case indicates that a long-standing growth hormone deficiency and hypogonadism may lead to LC as a type of burn-out non-alcoholic steatohepatitis.

Journal

  • 福岡醫學雜誌

    福岡醫學雜誌 107 (3), 53-61, 2016-03-25

    Fukuoka Medical Association

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