A case of hepatitis C-related cirrhosis that developed cancer of unknown primary origin and followed with fulminant course after treatment with direct-acting antivirals

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  • Tajima Kazuaki
    Department of Internal Medicine, Nagasaki Prefecture Gotochuoh Hospital Department of Gastroenterology and Heptology, Nagasaki University Graduate School of Biomedical Sciences
  • Fukushima Nobuyoshi
    Department of Internal Medicine, Nagasaki Prefecture Gotochuoh Hospital
  • Kira Keishi
    Department of Internal Medicine, Nagasaki Prefecture Gotochuoh Hospital Department of Gastroenterology and Heptology, Nagasaki University Graduate School of Biomedical Sciences
  • Togo Masaaki
    Department of Internal Medicine, Nagasaki Prefecture Gotochuoh Hospital
  • Shibata Masashi
    Department of Internal Medicine, Nagasaki Prefecture Gotochuoh Hospital
  • Mawatari Shogo
    Department of Internal Medicine, Nagasaki Prefecture Gotochuoh Hospital
  • Hayashi Hiroko
    Department of Pathology, Nagasaki University Graduate School of Biomedical Science
  • Shimokawa Isao
    Department of Pathology, Nagasaki University Graduate School of Biomedical Science
  • Takeshima Fuminao
    Department of Internal Medicine, Nagasaki Prefecture Gotochuoh Hospital
  • Nakao Kazuhiko
    Department of Gastroenterology and Heptology, Nagasaki University Graduate School of Biomedical Sciences

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Other Title
  • Direct acting antiviral治療後に原発不明癌を発症し急激な転機を辿ったC型肝硬変の1例
  • Direct acting antiviral チリョウ ゴ ニ ゲンパツ フメイガン オ ハッショウ シ キュウゲキ ナ テンキ オ タドッタ Cガタ カンコウヘン ノ 1レイ

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Abstract

<p>Here, we present a case of a female patient who was in her 70s. She was treated with IFN for hepatitis C-related compensated cirrhosis 8 years ago but had discontinued the treatment. She was given Daclatasvir hydrochloride+Asunaprevir 4 years ago; however, it was ineffective. She was given Sofosbuvir+Velpatasvir+Ribavirin 2 years and 4 months ago, and achieved SVR. She underwent partial hepatectomy, 7 months ago, for a single-moderately differentiated-3 cm hepatocellular carcinoma. In January X, she was admitted to the hospital because of multiple intrahepatic tumors shown on MRI. Further evaluation revealed tumors in the breasts and upper left arm and the patient died 1 month after admission. The pathological autopsy revealed that multiple systemic tumors were adenocarcinoma of unknown primary origin, except one hepatic tumor that was hepatocellular carcinoma. There are few reports of developing solid cancers other than hepatocellular carcinoma after treatment with direct-acting antivirals. Here, we report a similar case with a review of previously published literature on the same.</p>

Journal

  • Kanzo

    Kanzo 63 (2), 77-86, 2022-02-01

    The Japan Society of Hepatology

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