Three Cases of Diaphenylsulfone-induced Methemoglobinemia

  • Hokari Satoshi
    Department of Respiratory Medicine and Infectious Diseases, Niigata University Medical and Dental Hospital
  • Watarai-Kazama Hazuki
    Department of Respiratory Medicine and Infectious Diseases, Niigata University Medical and Dental Hospital Clinical Education Center, Niigata University Medical and Dental Hospital
  • Nagumo Shun
    Department of Respiratory Medicine and Infectious Diseases, Niigata University Medical and Dental Hospital
  • Ogata Hideyuki
    Department of Respiratory Medicine and Infectious Diseases, Niigata University Medical and Dental Hospital
  • Koizumi Takeshi
    Department of Respiratory Medicine and Infectious Diseases, Niigata University Medical and Dental Hospital
  • Ichikawa Kosuke
    Department of Respiratory Medicine and Infectious Diseases, Niigata University Medical and Dental Hospital
  • Aoki Nobumasa
    Department of Respiratory Medicine and Infectious Diseases, Niigata University Medical and Dental Hospital
  • Watanabe Satoshi
    Department of Respiratory Medicine and Infectious Diseases, Niigata University Medical and Dental Hospital
  • Koya Toshiyuki
    Department of Respiratory Medicine and Infectious Diseases, Niigata University Medical and Dental Hospital
  • Kikuchi Toshiaki
    Department of Respiratory Medicine and Infectious Diseases, Niigata University Medical and Dental Hospital

Bibliographic Information

Other Title
  • ジアフェニルスルホンによる薬剤性メトヘモグロビン血症の3例
  • ジアフェニルスルホン ニ ヨル ヤクザイセイ メトヘモグロビン ケッショウ ノ 3レイ

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<p>同一年で3例のジアフェニルスルホン(diaphenylsulfone:DDS)による薬剤性メトヘモグロビン(methemoglobin:MetHb)血症を経験した.3例とも皮膚科でDDSを処方されており,偶発的にSpO2低下を指摘され,動脈血液ガス分析でのSpO2とSaO2の乖離及びMetHb分画上昇で診断された.MetHb血症は軽症で,DDS中止のみで速やかに改善した.DDS内服中に呼吸不全と診断される症例には,薬剤性MetHb血症が潜んでいる可能性がある.</p>

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