CURRENT SITUATION OF ANAPHYLAXIS IN JAPAN: DATA FROM THE ANAPHYLAXIS REGISTRY OF TRAINING AND TEACHING FACILITIES CERTIFIED BY THE JAPANESE SOCIETY OF ALLERGY

DOI Web Site 2 Citations
  • Sato Sakura
    Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital
  • Yanagida Noriyuki
    Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital
  • Ito Komei
    Department of Allergy, Aichi Children's Health and Medical Center
  • Okamoto Yoshitaka
    Department of Otorhinolaryngology, Chiba Rosai Hospital
  • Saito Hirohisa
    Department of Allergy, National Center for Child Health and Development
  • Taniguchi Masami
    Department of Allergy, Shonan Kamakura General Hospital
  • Nagata Makoto
    Department of Respiratory Medicine, Saitama Medical University/Allergy Center, Saitama Medical University
  • Hirata Hirokuni
    Department of Respiratory Medicine and Clinical Immunology, Dokkyo Medical University Saitama Medical Center
  • Yamaguchi Masao
    Department of Internal Medicine, Teikyo University Chiba Medical Center
  • Pawankar Ruby
    Department of Pediatrics, Nippon Medical School
  • Ebisawa Motohiro
    Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital

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Other Title
  • 日本のアナフィラキシーの実態：日本アレルギー学会認定教育研修施設におけるアナフィラキシー症例の集積調査
  • ニホン ノ アナフィラキシー ノ ジッタイ : ニホン アレルギー ガッカイ ニンテイ キョウイク ケンシュウ シセツ ニ オケル アナフィラキシー ショウレイ ノ シュウセキ チョウサ

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Abstract

<p>Background: No nationwide epidemiological survey of anaphylaxis in Japan has been conducted. The aim of this study was to elucidate the triggers and treatment of anaphylaxis in Japan.</p><p>Methods: We prospectively collected clinical information on the triggers and treatment of patients who developed anaphylaxis or were admitted to the emergency room with anaphylaxis in the training and teaching facilities of the Japanese Society of Allergology between February 2015 and October 2017.</p><p>Results: Seventy-nine of 451 facilities (18%) participated in the study, and a total of 767 patients (under 18 years, 73%; in-hospital, 7%) were enrolled. The most common triggers were food (68%), drugs (12%), food-dependent exercise-induced anaphylaxis (5%), insects (4%), and oral immunotherapy (3%), with drugs being the most common in-hospital trigger and food being the most common out-of-hospital trigger. The intramuscular injection of adrenaline in medical institutions accounted for 38% of cases, 10% of which required multiple doses. The rate of use of adrenaline self-injections in out-of-hospital cases was 12%.</p><p>Conclusion: The present study revealed the most common triggers and treatment for anaphylaxis in Japan. Self-management at the onset of anaphylaxis and adrenaline administration as the initial treatment may be insufficient. Therefore, it is necessary to thoroughly instruct patients and educate physicians regarding anaphylaxis.</p>

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