Export of excess reactive sulfur species through cystine-dependent antiporters

DOI
  • AOKI Hanako
    Degree Programs in Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba
  • AKIYAMA Masahiro
    Faculty of Medicine, University of Tsukuba Faculty of Pharmacy, Keio University
  • UNOKI Takamitsu
    Faculty of Medicine, University of Tsukuba Hygienic Chemistry Section, Department of Basic Medical Sciences, National Institute for Minamata Disease
  • WARABI Eiji
    Degree Programs in Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba Faculty of Medicine, University of Tsukuba
  • NISHIMURA Akiyuki
    Division of Cardiocirculatory Signaling, National Institute for Physiological Sciences
  • NISHIDA Motohiro
    Division of Cardiocirculatory Signaling, National Institute for Physiological Sciences
  • KUMAGAI Yoshito
    Degree Programs in Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba Faculty of Medicine, University of Tsukuba

Bibliographic Information

Other Title
  • シスチン要求性アンチポーターを介した過剰な活性イオウ分子の細胞外排出

Description

<p>Reactive sulfur species (RSS) exhibit high nucleophilicity/antioxidative property and thus is thought to play an important role in repressing electrophilic/oxidative stress. On the other hand, excess amount of RSS (sulfur stress) may disrupt redox homeostasis and increase health risk. Here, we examined adaptive response against intracellular sulfur stress. The present study suggests that there are cystine-dependent antiporters including SLC7A11 to excrete excess intracellular CysSSH.</p>

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