HHV8-negative primary effusion lymphoma-like lymphoma with abnormally high levels of KL-6 suspected to be tumor-associated

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  • AKATSUKA Takanori
    Central Clinical laboratory Kohsei Chuo General Hospital Graduate School of Arts and Sciences, The Open University of Japan
  • AOTA Yasuo
    Central Clinical laboratory Kohsei Chuo General Hospital Internal Medicine Kohsei Chuo General Hospital Department of Hematology, Tokyo Medical University
  • NOGUCHI Naoki
    Central Clinical laboratory Kohsei Chuo General Hospital
  • IDESAWA Mai
    Central Clinical laboratory Kohsei Chuo General Hospital
  • NISHIZONO Akimasa
    Central Clinical laboratory Kohsei Chuo General Hospital
  • GOTOH Akihiko
    Internal Medicine Kohsei Chuo General Hospital Department of Hematology, Tokyo Medical University

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  • 腫瘍随伴性が疑われるKL-6異常高値を呈したHHV8陰性primary effusion lymphoma like lymphoma
  • シュヨウ ズイハンセイ ガ ウタガワレル KL-6 イジョウ タカネ オ テイシタ HHV8 インセイ primary effusion lymphoma like lymphoma

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Abstract

<p>A 64-year-old woman with anorexia since February 2022, followed by abdominal distention despite reduced food intake, visited a hospital in September. She underwent abdominal CT, which revealed liver cirrhosis and a large amount of ascites effusion. After performing an abdominocentesis and histopathological examination, a diagnosis of HHV8-negative primary effusion lymphoma (PEL)-like lymphoma was made. The patient was transferred to our hospital for further treatment. The blood test performed upon admission showed an abnormally high level of KL-6 (24,141 U/mL). Since KL-6 levels decreased gradually after chemotherapy for HHV8-negative PEL-like lymphoma, we hypothesized that KL-6 might be derived from HHV8-negative PEL-like lymphoma.</p>

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