A Hemoglibin Varitant, Hb Hoshida, Resulted in Discrepancies Between Glycohemoglibin Analyzers

DOI
  • Kuriyama Mana
    Division of Diabetes and Endocrinology, Department of Internal Medicine, Kanto Rosai Hospital
  • Nakato Misa
    Division of Diabetes and Endocrinology, Department of Internal Medicine, Kanto Rosai Hospital
  • Hata Yusuke
    Division of Diabetes and Endocrinology, Department of Internal Medicine, Kanto Rosai Hospital
  • Matsuda Mizusa
    Division of Diabetes and Endocrinology, Department of Internal Medicine, Kanto Rosai Hospital
  • Murata Mariko
    Division of Diabetes and Endocrinology, Department of Internal Medicine, Kanto Rosai Hospital
  • Horiguchi Kyohei
    Division of Diabetes and Endocrinology, Department of Internal Medicine, Kanto Rosai Hospital
  • Ide Yuki
    Division of Clinical Laboratory, Kanto Rosai Hospital
  • Abekawa Takashi
    Division of Clinical Laboratory, Kanto Rosai Hospital
  • Hamano Kumiko
    Division of Diabetes and Endocrinology, Department of Internal Medicine, Kanto Rosai Hospital
  • Nagai Yoshio
    Division of Diabetes and Endocrinology, Department of Internal Medicine, Kanto Rosai Hospital

Bibliographic Information

Other Title
  • グリコヘモグロビン分析計の機器間で異なる結果を示した異常へモグロビンHoshidaの1例

Description

<p>When measuring hemoglobin A1c (HbA1c) using high-performance liquid chromatography (HPLC), the chromatogram may trigger suspicion of variant hemoglobin. We present the case of a 60-year-old man. When the patient was 50 years of age, HPLC showed an extra peak in the patient's HbA1c chromatogram (HLC-723 G8 and G9, Toso). Accordingly, variant hemoglobin was suspected. He was diagnosed with diabetes mellitus at 52 years of age. Subsequently, the patient did not visit our hospital for 8 years because he moved away. Upon his return, his HbA1c level was 6.1 % on HPLC (HLC-723 G11), but an enzymatic assay of the same sample yielded an HbA1c level of 8.6 %. Although HPLC showed no abnormal peaks, isoelectric electrophoresis showed abnormal bands. The globin gene was analyzed with the patient's consent, leading to a diagnosis of variant hemoglobin and hemoglobin Hoshida. This case shows that the results can differ depending on the glycohemoglobin analyzer that is used. This variability must be carefully considered during the diagnosis of variant hemoglobin.</p>

Journal

Keywords

Details 詳細情報について

  • CRID
    1390301684514676864
  • DOI
    10.11213/tonyobyo.67.394
  • ISSN
    1881588X
    0021437X
  • Text Lang
    ja
  • Data Source
    • JaLC
  • Abstract License Flag
    Disallowed

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