Emulsified Fucoxanthin Increases Stability and Absorption in Rats

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  • Kumagai Kota
    Healthcare Products Development Center, KYOWA HAKKO BIO CO., LTD. Department of Bioresources Science, The United Graduate School of Agricultural Sciences, Iwate University
  • Nebashi Naohiro
    Healthcare Products Development Center, KYOWA HAKKO BIO CO., LTD.
  • Muromachi Ayako
    Healthcare Products Development Center, KYOWA HAKKO BIO CO., LTD.
  • Nakano Yuichiro
    Healthcare Products Development Center, KYOWA HAKKO BIO CO., LTD.
  • Ito Yoshiaki
    Department of Biological Chemistry and Food Sciences, Faculty of Agriculture, Iwate University
  • Nagasawa Takashi
    Department of Biological Chemistry and Food Sciences, Faculty of Agriculture, Iwate University

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Other Title
  • 乳化製剤化したフコキサンチンの安定性とラットにおける吸収性
  • ニュウカ セイザイカ シタ フコキサンチン ノ アンテイセイ ト ラット ニ オケル キュウシュウセイ
  • Emulsified fucoxanthin increases stability and absorption in rats. Nippon

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Abstract

<p>Fucoxanthin, one of the xanthophylls in brown seaweeds, has various physiological functions; however, its bioavailability and stability are low. We examined whether emulsification of fucoxanthin improves its stability and absorption into the body. Emulsified fucoxanthin powder was prepared using gum arabic as emulsifier and γ-cyclodextrin as stabilizer, respectively. Fucoxanthin in the emulsified formulation remained at more than 90% after exposure to 40°C for 4 months, while fucoxanthin without emulsification decreased to undetectable levels within one month. Thus, the stability of fucoxanthin was improved by emulsification. In a kinetic study in rats, we evaluated fucoxanthinol levels in plasma, liver, kidney, and skeletal muscle. Fucoxanthin is hydrolysed to fucoxanthinol in the gastrointestinal tract by enzymes such as lipase, and fucoxanthinol is then absorbed into the body. Fucoxanthinol levels in plasma and tissues were significantly greater with the emulsified fucoxanthin formulation than the equivalent unemulsified formulation, which barely increased the levels. Thus, fucoxanthin was absorbed efficiently into the body following emulsification. In conclusion, emulsification of fucoxanthin using gum arabic and γ-cyclodextrin increased both its stability and bioavailability.</p>

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