Dynamics of Intracellular Metabolites in <i>Mycobacterium leprae</i>

DOI Web Site Web Site 6 References
  • Miyamoto Yuji
    Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases

Bibliographic Information

Other Title
  • らい菌における菌体内代謝産物の動態解析
  • ライ キン ニ オケル キンタイ ナイ タイシャ サンブツ ノ ドウタイ カイセキ

Search this article

Description

<p>  Mycobacterium leprae, the causative agent of leprosy, possesses unique features including inability to proliferate in vitro. In the cellular components of M. leprae, the fate of intracellular metabolites, assumed to be associated with such physiology, remain largely unknown. In this study, we found that amino acid species are significantly accumulated, while most of intermediates related to central carbon metabolism markedly decreased, in the intracellular metabolite fraction of M. leprae, as compared with that of other mycobacteria. Our results show the unique metabolite dynamics of M. leprae for the first time and these insights might contribute to understanding the physiological characteristics of leprosy.</p>

Journal

References(6)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top