書誌事項
- タイトル別名
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- Pharmaceutical Properties of Jelly Dosage Form Containing Calcium Polystyrene Sulfonate
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説明
<p>To reduce the gritty feeling of orally administered calcium polystyrene sulfonate powder (PS-Ca), we have developed a jelly dosage form containing PS-Ca. The jelly form (PS-Ca jelly), containing gelatin, carrageenan, and pectin, was confirmed to show a less gritty feeling when it was evaluated by the human volunteer's sensory test. Moreover, these additives seemed to regulate its adhesiveness and cohesiveness. In vitro potassium exchange profiles of PS-Ca jelly obtained by the press-through method and the paddle bead method showed no difference between PS-Ca jelly and PS-Ca powder (Kalimate®), which was selected as a reference dosage form. A bioequivalence test of these forms was also performed with measuring serum potassium concentration changes, using nephrectomized rats. No statistically significant difference was found. The physical appearance of PS-Ca jelly stored at 60°C for 28 days remained unchanged, and the loss of water was within 2%. We have concluded that the newly formulated PS-Ca jelly will be able to contribute to the improvement of a patient's QOL.</p>
収録刊行物
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- 薬剤学
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薬剤学 60 (4), 261-270, 2000
公益社団法人 日本薬剤学会
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詳細情報 詳細情報について
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- CRID
- 1390564238091941632
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- NII論文ID
- 10013264769
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- NII書誌ID
- AN00266708
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- ISSN
- 21883149
- 03727629
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
