Comparison of the Efficacy of Cryoballoon Ablation for Paroxysmal and Persistent Atrial Fibrillation

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  • Iso Kazuki
    Division of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
  • Watanabe Ichiro
    Division of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
  • Okumura Yasuo
    Division of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
  • Nagashima Koichi
    Division of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
  • Takahash Keiko
    Division of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
  • Arai Masaru
    Division of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
  • Watanabe Ryuta
    Division of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
  • Kurokawa Sayaka
    Division of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
  • Ohkubo Kimie
    Division of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
  • Nakai Toshiko
    Division of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
  • Hirayama Atsushi
    Division of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
  • Sonoda Kazumasa
    Division of Cardiology, Department of Medicine, Tokyo Rinkai Hospital., Tokyo, Japan
  • Tosaka Toshimasa
    Division of Cardiology, Department of Medicine, Tokyo Rinkai Hospital., Tokyo, Japan

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Background: Similar clinical outcomes have been demonstrated following pulmonary vein (PV) isolation (I) by radiofrequency catheter and cryoballoon ablation (CBA) in patients with paroxysmal atrial fibrillation (PAF). However, no comparison of the clinical outcome in patients with PAF and persistent AF (PerAF) by CBA has been reported to date. The purpose of this study was to compare the efficacy of PVI in patients with PAF and PerAF. Methods: CBA based PVI using a second-generation 28-mm balloon was performed in 58 patients with PAF and 32 with PerAF. Follow-up (FU) was based on outpatient clinic visits at 1, 3, 6, and 12 months, which included Holter electrocardiograms and ambulatory event electrocardiograms. Results: The freedom from atrial tachyarrhythmia recurrences following a single cryoballoon ablation in patients with PAF and PerAF did not differ significantly between the PAF and PerAF patients over a relatively shorter follow-up period, as estimated by the Kaplan-Meir method. Conclusion: CB-based PVI had similar efficacy for both PAF and PerAF.

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