Assessment of the effect and safety of salacinol in horses

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  • UEDA Fumitaka
    Bio Science & Engineering Laboratory, Research & Development Management Headquarters, FUJIFILM Corporation, Kanagawa 258-8577, Japan
  • IIDA Atsushi
    Bio Science & Engineering Laboratory, Research & Development Management Headquarters, FUJIFILM Corporation, Kanagawa 258-8577, Japan
  • SAITO Hitomi
    Bio Science & Engineering Laboratory, Research & Development Management Headquarters, FUJIFILM Corporation, Kanagawa 258-8577, Japan
  • SEKI Shinobu
    Bio Science & Engineering Laboratory, Research & Development Management Headquarters, FUJIFILM Corporation, Kanagawa 258-8577, Japan
  • AMAO Akihito
    Highly Functional Materials Business Development Headquarters, FUJIFILM Corporation, Tokyo 107-0052, Japan
  • YAMATE Hirotsugu
    Yamate Racehorse Clinic, Iwate 020-0103, Japan

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<p>We report a study that examined the effect and safety of salacinol from Salacia reticulata extract (SRE) for the intestinal microbiota of horses. We administered SRE to healthy horses and evaluated their intestinal microbiota before and after the test period for changes in composition. Horses that received the SRE showed notable differences in intestinal microbiota composition between before and after administration, with a substantial increase in bacteria of the order Lactobacillales at the end of the test period. Moreover, the Firmicutes-to-Bacteroidetes ratio was elevated. Salacinol was administered as a supplement for 28 days. Physiological and blood tests were conducted in the presence of a veterinarian, and a safety assessment was performed. These evaluations revealed no detrimental findings.</p>

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