A Mechanism of Cancer Cell Cytotoxicity of Near-Infrared Photoimmunotherapy

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  • Sato Kazuhide
    Nagoya University Institute for Advanced Research, S-YLC Nagoya University Institute for Advanced Research, B3-Unit, Advanced Analytical and Diagnostic Imaging Center (AADIC)/Medical Engineering Unit (MEU) Respiratory Medicine, Nagoya University Graduate School of Medicine

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  • 近赤外光線免疫療法のメカニズムの解明

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<p>Near-infrared photoimmunotherapy (NIR-PIT) is a recently developed next-generation cancer photo-target therapy that combines the specificity of intravenously injected antibodies for targeting tumors with toxicity induced by photoabsorber (IR700) after exposure to NIR-light. NIR-PIT is realized its multidisciplinary method with the combination of the technologies in chemistry, biolody, pharmacology and physics. Presently, NIR-PIT is under the international phase III clinical trial against locoregional, recurrent head and neck SCC (HNSCC) (LUZERA-301, NCT03769506) with FDA fast track approval and expected to be clinically licensed in a few years. However, the precise mechanism of NIR-PIT is still unknown. In this review, the scheme of NIR-PIT and the mechanism of NIR-PIT is outlined.</p>

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