Cyclic Sulfamidite as Simultaneous Protecting Group for Amino Alcohols: Development of a Mild Deprotection Protocol Using Thiophenol
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- Sakata Juri
- Graduate School of Pharmaceutical Sciences, Tohoku University
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- Akita Kazunari
- Graduate School of Pharmaceutical Sciences, Tohoku University
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- Sato Manabu
- Graduate School of Pharmaceutical Sciences, Tohoku University
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- Shimomura Masashi
- Graduate School of Pharmaceutical Sciences, Tohoku University
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- Tokuyama Hidetoshi
- Graduate School of Pharmaceutical Sciences, Tohoku University
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Description
<p>This study describes the novel utility of cyclic sulfamidite as a simultaneous protecting group for 1,2- or 1,3-amino alcohols. An exceptionally mild and neutral condition for the removal of the cyclic sulfamidite was developed. The deprotection condition demonstrated a broad range of functional-group compatibility, including a substrate bearing a Z-enyne structure without any loss of double-bond stereochemistry.</p>
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 68 (10), 996-1000, 2020-10-01
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390567172583424000
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- NII Article ID
- 130007920334
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- NII Book ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL BIB ID
- 030662161
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- PubMed
- 32999152
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed