Sex differences in the influence of elevated serum uric acid levels for cardiovascular risk in the general population with normal renal function

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  • Matsuura Yuki
    Division of Nephrology and Hypertension, Department of Internal Medicine, School of Medicine, Iwate Medical University, Yahaba, Japan
  • Tanaka Fumitaka
    Division of Nephrology and Hypertension, Department of Internal Medicine, School of Medicine, Iwate Medical University, Yahaba, Japan
  • Segawa Toshie
    Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Yahaba, Japan
  • Tanno Kozo
    Department of Hygiene and Preventive Medicine, School of Medicine, Iwate Medical University, Yahaba, Japan
  • Sakata Kiyomi
    Department of Hygiene and Preventive Medicine, School of Medicine, Iwate Medical University, Yahaba, Japan
  • Ohsawa Masaki
    Department of Internal Medicine, Morioka Tsunagi Onsen Hospital
  • Omama Shinichi
    Emergency and Critical Care Center, School of Medicine, Iwate Medical University, Yahaba, Japan
  • Ogasawara Kuniaki
    Department of Neurosurgery, School of Medicine, Iwate Medical University, Yahaba, Japan
  • Asahi Koichi
    Division of Nephrology and Hypertension, Department of Internal Medicine, School of Medicine, Iwate Medical University, Yahaba, Japan
  • Nakamura Motoyuki
    Professor Emeritus, School of Medicine, Iwate Medical University, Yahaba, Japan

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Other Title
  • 腎機能正常な一般住民における血清尿酸値と心血管疾患発症の関連，性差について

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Abstract

The role of serum uric acid (SUA) as an independent predictor of cardiovascular events (CVEs) is uncertain, as previous studies may not have sufficiently accounted for risk factors that are strongly related to the SUA level, such as chronic kidney disease (CKD). We examined the association between the SUA level and the incidence of CVEs in each gender without CKD. Baseline data, including the SUA level, estimated glomerular filtration rate, and urinary albumin/creatinine ratio were determined in participants from a community-based population. After the exclusion of CKD, the subjects were stratified into sex-specific quartiles of SUA (n = 15,036). A Cox regression analysis was performed to examine the sex-specific relationship between the baseline SUA level and the onset of CVEs. During a mean follow-up period of 8.8 years, there were 611 CVEs (304 in men, 307 in women). After adjusting for traditional risk factors, the hazard ratio for the onset of CVEs did not differ among the quartiles in men. In contrast, in women, a significant trend was observed. In the Japanese general population without CKD, moderately elevated SUA level is considered an independent risk factor for the onset of CVEs in women but not in men.

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