生体防御は個体発生を繰り返す : γδ型T細胞と感染防御

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  • 吉開 泰信
    九州大学生体防御医学研究所附属感染ネットワーク研究センター感染制御学分野

書誌事項

タイトル別名
  • The Roles of γδ T Cells in Host Defense Against Microbial Infection
  • セイタイ ボウギョ ワ コタイ ハッセイ オ クリカエス : gdガタ Tサイボウ ト カンセン ボウギョ

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抄録

In the thymus, two types of T cells develop : γδ T cell receptor (TCR)-positive cells, which develop from the CD4^-CD8^- double-negative (DN) stage, whereas cell populations that enter the CD4^+CD8^+ double-positive (DP) stage become αβ T cells. Unlike conventional αβ T cells, which are exported from the thymus as naïve cells and acquire effector functions upon encountering antigen in the periphery, γδ T cells are functionally committed to forming effector cells that produce inflammatory cytokines such as interferon (IFN)-g and interleukin (IL)-17 and mount cytotoxic responses upon activation within the thymus and are disproportionately distributed within mucosal epithelia such as reproductive tracks, intestine and skin. These features allow γδ T cells to respond to antigens quickly without clonal expansion and function as the first line of host defense against microbial infection. Thereby I call the γδ T cells “primitive T cells”. I propose, a hypothesis “hose defense recapitulates ontogeny” on the basis of research on the γδ T cells as primitive T cells and challenge the conventional immunological paradigm to be sub-classified into innate and adaptive immunity.

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