Novel Elongated Phosphoranes by Heck-Reaction and Pd(0)-Catalysed Alkynylation and their Use in C-7 Group Functionalisation in Estrones
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- ティーマン ティース
- 九州大学機能物質科学研究所
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- Umeno Kuniharu
- Graduate School of Engineering Sciences Kyushu University
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- Inohae Eiko
- Graduate School of Engineering Sciences Kyushu University
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- 又賀 駿太郎
- 九州大学機能物質科学研究所
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抄録
Halobenzoylmethylidenephosphoranes 3 are reacted under C-C bond formation to give a number of novel elongated phosphoranes 5 and 6. The C-C bond formation could be achieved both under Heck conditions and by metal-catalyzed ethynylation reaction. The products, desactivated phosphoranes, can be reacted in Wittig-olefinations with aldehydes. Exemplary use of the phosphoranes is shown in the C-7 chain functionalisation in synthetic estrones, which may be valuable precursors for radioligands in early breast cancer diagnosis.
収録刊行物
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- 九州大学機能物質科学研究所報告
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九州大学機能物質科学研究所報告 14 (1), 17-29, 2000-07-01
九州大学機能物質科学研究所
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詳細情報 詳細情報について
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- CRID
- 1390572174788966400
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- NII論文ID
- 110006177566
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- NII書誌ID
- AN10060378
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- ISSN
- 09143793
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- DOI
- 10.15017/7917
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- HANDLE
- 2324/7917
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- NDL書誌ID
- 5466537
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用可