Mannose-binding analysis and biological application of pradimicins

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  • NAKAGAWA Yu
    Institute for Glyco-core Research (iGCORE), Nagoya University RIKEN Cluster for Pioneering Research
  • ITO Yukishige
    RIKEN Cluster for Pioneering Research Graduate School of Science, Osaka University

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<p>Pradimicins (PRMs) are an exceptional family of natural products that specifically bind d-mannose (Man). In the past decade, their scientific significance has increased greatly, with the emergence of biological roles of Man-containing glycans. However, research into the use of PRMs has been severely limited by their inherent tendency to form water-insoluble aggregates. Recently, we have established a derivatization strategy to suppress PRM aggregation, providing an opportunity for practical application of PRMs in glycobiological research. This article first outlines the challenges in studying Man-binding mechanisms and structural modifications of PRMs, and then describes our approach to address them. We also present our recent attempts toward the development of PRM-based research tools.</p>

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