Mannose-binding analysis and biological application of pradimicins
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- NAKAGAWA Yu
- Institute for Glyco-core Research (iGCORE), Nagoya University RIKEN Cluster for Pioneering Research
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- ITO Yukishige
- RIKEN Cluster for Pioneering Research Graduate School of Science, Osaka University
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説明
<p>Pradimicins (PRMs) are an exceptional family of natural products that specifically bind d-mannose (Man). In the past decade, their scientific significance has increased greatly, with the emergence of biological roles of Man-containing glycans. However, research into the use of PRMs has been severely limited by their inherent tendency to form water-insoluble aggregates. Recently, we have established a derivatization strategy to suppress PRM aggregation, providing an opportunity for practical application of PRMs in glycobiological research. This article first outlines the challenges in studying Man-binding mechanisms and structural modifications of PRMs, and then describes our approach to address them. We also present our recent attempts toward the development of PRM-based research tools.</p>
収録刊行物
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- Proceedings of the Japan Academy. Ser. B: Physical and Biological Sciences
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Proceedings of the Japan Academy. Ser. B: Physical and Biological Sciences 98 (1), 15-29, 2022-01-11
日本学士院
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詳細情報 詳細情報について
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- CRID
- 1390572244904900608
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- NII論文ID
- 130008140762
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- NII書誌ID
- AA00785485
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- ISSN
- 13492896
- 03862208
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- NDL書誌ID
- 031944179
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- PubMed
- 35013028
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可