Isolation and Characterization of Nocardia Species from Pulmonary Nocardiosis in a Tertiary Hospital in China

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  • Li Jun
    Department of Clinical Laboratory, Xiangya Hospital, Central South University, China
  • Shen Hui
    Department of Clinical Laboratory, the First Hospital of Changsha, China
  • Yu Ting
    Department of Clinical Laboratory, Xiangya Hospital, Central South University, China
  • Tao Xiao-Yan
    Department of Clinical Laboratory, Xiangya Hospital, Central South University, China
  • Hu Yong-Mei
    Department of Clinical Laboratory, Xiangya Hospital, Central South University, China
  • Wang Hai-Chen
    Department of Clinical Laboratory, Xiangya Hospital, Central South University, China
  • Zou Ming-Xiang
    Department of Clinical Laboratory, Xiangya Hospital, Central South University, China

書誌事項

タイトル別名
  • Isolation and Characterization of <i>Nocardia</i> Species from Pulmonary Nocardiosis in a Tertiary Hospital in China
公開日
2022-01-31
資源種別
journal article
DOI
  • 10.7883/yoken.jjid.2020.1096
公開者
国立感染症研究所

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説明

<p>This study aimed to investigate the clinical features, distribution, and antimicrobial susceptibility of Nocardia species isolated from pulmonary nocardiosis cases in a tertiary hospital in China. The species were collected from January 1, 2018, to May 31, 2019, and identified using Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry or polymerase chain reaction. Antimicrobial susceptibility testing was performed using the broth microdilution method. Within the 44 Nocardia species, N. farcinica was the most frequently identified species (n = 36), followed by N. nova (n = 5), N. otitidiscaviarum (n = 1), N. cyriacigeorgica (n = 1), and N. transvalensis (n = 1). The top 3 predisposing factors of pulmonary nocardiosis were chronic obstructive pulmonary disease (45.5%), hypertension (34.1%), and tuberculosis (31.8%). All 44 Nocardia species were susceptible to amikacin, trimethoprim/sulfamethoxazole, and linezolid. The resistance rates of Nocardia to amoxicillin-clavulanic acid, ciprofloxacin, clarithromycin, ceftriaxone, tobramycin, and imipenem were 4.5%, 9.1%, 79.5%, 72.7%, 63.6%, and 38.6%, respectively. Two Nocardia strains had decreased sensitivity to trimethoprim/sulfamethoxazole. In conclusion, N. farcinica was the most frequently isolated Nocardia species in the First Hospital of Changsha. All the isolated clinical Nocardia species showed susceptibility to amikacin, trimethoprim/sulfamethoxazole, and linezolid, suggesting that these drugs can be primary therapeutic choices for treating Nocardia infections.</p>

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