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- 片岡 裕美
- 武庫川女子大学薬学部薬学科衛生化学研究室
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- 田中 かおり
- 武庫川女子大学薬学部薬学科衛生化学研究室
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- 村山(田鶴谷) 惠子
- 第一薬科大学薬学部薬学教育推進センター
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- 山下 沢
- 武庫川女子大学薬学部薬学科衛生化学研究室
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- 西川 淳一
- 武庫川女子大学薬学部薬学科衛生化学研究室
書誌事項
- タイトル別名
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- Effects of Coarse and Fine Atmospheric Particulate Matter on a Mast Cell Line
- ソダイ オヨビ ビショウ タイキ リュウシジョウ ブッシツ ガ マスト サイボウカブ ニ オヨボス エイキョウ
この論文をさがす
抄録
<p>We investigated the cytotoxicity on a mast cell line (C57 cells) of water-soluble extracts of coarse (>3 µm, PM>3) and fine (0.05–3 µm, PM0.05–3) atmospheric particulates collected from April 2016 to March 2019 in Fukuoka, Japan. We examined the direct cytotoxicity with punched-out membrane filter fragments of PM>3 and PM0.05–3 collected from April 2019 to March 2021, without extraction of the components. Also, cell proliferation and degranulation assays were conducted under conditions which caused no cytotoxicity with water-soluble extracts of PM>3 from FY2016 and PM>3 direct samples from FY2019. The findings revealed the significant direct cytotoxicity of many PM>3 and all PM0.05–3 samples, with higher cytotoxicity for PM0.05–3 (FY2019–2020). These results were different from the cytotoxicity effects of water-soluble extracts of PM>3 and PM0.05–3 samples (FY2016) in previous studies. In addition, inhibition of cell proliferation and induction of degranulation were significantly induced in a few PM>3 samples, showing a correlation with the suspended particulate matter (SPM) concentrations. This method using punched-out membrane filters is convenient and useful for assessing the direct effects of atmospheric particles on a small scale.</p>
収録刊行物
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- 薬学雑誌
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薬学雑誌 143 (2), 159-170, 2023-02-01
公益社団法人 日本薬学会
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390576435496452480
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- NII書誌ID
- AN00284903
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- ISSN
- 13475231
- 00316903
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- NDL書誌ID
- 032678348
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
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- 抄録ライセンスフラグ
- 使用不可