A 94-year-old Woman Diagnosed With Slowly Progressive Type 1 Diabetes Mellitus (SPIDDM) Who Required Insulin Therapy

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  • Hatayama Tomomi
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University Department of Internal Medicine, Chikugogawa Onsen Hospital
  • Yokomizo Hisashi
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University Department of Endocrinology, Metabolism and Diabetes, Kyushu University Hospital Department of Endocrinology and Diabetes Mellitus, Fukuoka University Hospital
  • Miyazawa Takashi
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University Department of Endocrinology, Metabolism and Diabetes, Kyushu University Hospital
  • Sakamoto Ryuichi
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University Department of Endocrinology, Metabolism and Diabetes, Kyushu University Hospital
  • Miyamoto Tetsuya
    Department of Internal Medicine, Chikugogawa Onsen Hospital
  • Ogawa Yoshihiro
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University Department of Endocrinology, Metabolism and Diabetes, Kyushu University Hospital

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Other Title
  • 94歳で新規発症，インスリン療法を必要とした緩徐進行1型糖尿病の1例

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<p>We report the case of a 95-year-old woman who had been diagnosed with diabetes mellitus with HbA1c 9.7 % and a fasting blood glucose level of 199 mg/dL at 94 years of age. Despite the administration of oral hypoglycemic therapy for 5 months, her blood glucose was poorly controlled. On admission, we found that her HbA1c was 11.0 %, her casual blood glucose was 394 mg/dL and her glutamic acid decarboxylase antibody titer was 1740 U/mL (ELISA); she was then diagnosed with SPIDDM. While the development of SPIDDM is commonly reported in patients in their 40s to 50s, recent studies showed that around 10 % of elderly patients who developed diabetes were diagnosed with SPIDDM. We searched clinical characteristics of latter-stage elderly patients who developed SPIDDM and found that majority were female and showed reduced insulin secretion with poor glycemic control. It is important to consider the possibility of type 1 diabetes, including SPIDDM, even in elderly patients who have developed diabetes with poor glycemic control.</p>

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