Cellular characterization of hiPS CMs cultured on PMEA analogous polymers with different bound water content
この論文をさがす
説明
In recent years, human iPS cell-derived cardiomyocytes (hiPS-CMs) have attracted much attention in the arena of regenerative therapies. However, hiPS-CMs are known to be immature and have lower contractility than the adult heart. In this study, we investigated the effect of material properties of scaffold surfaces on hiPS-CMs with the aim of improving the contractility of hiPS-CMs. PMEA analogs with varying surface-bound water content, which affect cell adhesion/proliferation behavior, were selected as scaffold materials to coat PET substrates. The cell characteristics of the hiPS-CMs seeded on the scaffolds were evaluated. The initial cell adhesion area tended to be smaller on substrates with a higher amount of bound water. With further incubation, the hiPS-CMs formed self-pulsating aggregates on the substrate. On the substrates with high bound water content, the area of the hiPS-CMs aggregates tended to be smaller while the pulsation behavior became greater. The results indicate that PMEA analogues might affect the cellular properties of hiPS-CMs.
収録刊行物
-
- 九州大学大学院総合理工学報告
-
九州大学大学院総合理工学報告 45 (1), 1-6, 2023-09
九州大学大学院総合理工学府
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390577431256360960
-
- NII書誌ID
- AA1147319X
-
- DOI
- 10.15017/6786935
-
- HANDLE
- 2324/6786935
-
- ISSN
- 13467883
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- IRDB
- OpenAIRE
-
- 抄録ライセンスフラグ
- 使用可
