ST合剤耐性の<i>Nocardia wallacei</i>による肺ノカルジア症をclavulanic acid/amoxicillinで治療しえた1例

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  • A Case of Pulmonary Nocardiosis Caused by Trimethoprim-Sulfamethoxazole-Resistant <i>Nocardia wallacei</i> treated with Clavulanic acid/Amoxicillin

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<p>An 86-year-old woman with a 6-year history of bronchiectasis and recurrent pneumonia in the right lung presented to our hospital with a several weeks' history of bloody sputum. Imaging studies showed ground-glass and infiltrative opacities in the right lung, and Nocardia species were repeatedly isolated on sputum culture testing. Genetic testing identified Nocardia wallacei, which was resistant to sulfamethoxazole/trimethoprim. Therefore, the patient was treated with clavulanic acid/amoxicillin (CVA/AMPC) for a total of 6 months, and the symptoms, including the bloody sputum and cough, as well as the imaging findings, improved. Pulmonary nocardiosis can occur in patients with chronic lung disorders such as bronchiectasis, even in the absence of immunodeficiencies. Trimethoprim-sulfamethoxazole is the drug of first choice for nocardiosis, but identification of the Nocardia species and susceptibility testing are recommended for treatment, because the susceptibility varies with the species.</p>

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  • 感染症学雑誌

    感染症学雑誌 97 (4), 136-140, 2023-07-20

    一般社団法人 日本感染症学会

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