Solitary lung metastasis following resection of gastrointestinal stromal tumor in rectum

DOI Web Site 9 References
  • Kobayashi Masao
    Department of Chest Surgery, Osaka Police Hospital Department of Chest Surgery, Osaka University Hospital
  • Ishida Daisuke
    Department of Chest Surgery, Osaka Police Hospital
  • Sakamaki Yasushi
    Department of Chest Surgery, Osaka Police Hospital

Bibliographic Information

Other Title
  • 直腸GIST単発肺転移の一切除例

Search this article

Abstract

<p>A 79-year-old woman underwent resection of a gastrointestinal stromal tumor (GIST) in the rectum. Adjuvant chemotherapy with imatinib was administered for 1.5 years after surgery, and then stopped because of adverse events including nausea and anorexia (Grade 2). Computed tomography showed a 1.4-mm solitary pulmonary nodule in the right middle lobe at 4.5 years after the resection procedure, which gradually increased to 6.4 mm after 7 years. The patient was referred to our institution, as the nodule was suspected to be pulmonary malignancy. A partial resection of the lung was performed and histological examination results led to a diagnosis of pulmonary recurrence of GIST. Since imatinib therapy had adverse effects and was poorly tolerated, the patient was initially observed without any systemic therapy. At 4 months after the lung surgery, new sites of recurrence were found in the 11th rib and left ilium bone. Chemotherapy with imatinib at a reduced dose was administered, which allowed the patient to achieve stable disease. Findings in the present case indicate that even complete resection of a solitary pulmonary metastatic GIST may not achieve complete remission, and imatinib therapy should be considered.</p>

Journal

References(9)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top