The forefront of Oxidized Lipid Research: From Detection and Structural Analysis to Disease Control

DOI
  • Yamada Ken-ichi
    Department of Molecular Pathobiology, Faculty of Pharmaceutical Sciences, Kyushu University

Bibliographic Information

Other Title
  • 酸化脂質研究の最前線　～検出・構造解析から疾患制御へ～

Description

Recently, lipid-derived radicals and oxidized lipids have been reported to be closely involved in cell death (especially, ferroptosis) and inflammatory reactions and have attracted much attention. Therefore, inhibitors targeting oxidized lipids, especially lipid-derived radicals important in lipid peroxidation reactions, also called radical-trapping antioxidants (RTAs) , have been actively studied. In this article, we describe the detection and structural analysis techniques for lipid radicals and oxidized lipids and review more recent findings on new compound screening systems for RTA.

Journal

  • MEDCHEM NEWS

    MEDCHEM NEWS 34 (1), 30-35, 2024-02-01

    The Pharmaceutical Society of Japan

Keywords

Details 詳細情報について

  • CRID
    1390580472188585472
  • DOI
    10.14894/medchem.34.1_30
  • ISSN
    24328626
    24328618
  • Text Lang
    ja
  • Data Source
    • JaLC
  • Abstract License Flag
    Disallowed

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