タンパク質の凝集と免疫原性の調整 —リゾチーム研究を起点として—

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  • Modulation of Aggregation and Immunogenicity of a Protein: Based on the Study of Hen Lysozyme

抄録

<p>This study focuses on the modulation of protein aggregation and immunogenicity. As a starting point for investigating long-range interactions within a non-native protein, the effects of perturbing denatured protein states on their aggregation, including the formation of amyloid fibrils, were evaluated. The effects of adducts, sugar modifications, and stabilization on protein aggregation were then examined. We also investigated how protein immunogenicity was affected by enhancing protein conformational stability and other factors.</p>

収録刊行物

  • 薬学雑誌

    薬学雑誌 144 (3), 299-310, 2024-03-01

    公益社団法人 日本薬学会

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