Botulinum Toxin Mechanisms for Orofacial Pain

DOI
  • Matsuka Yoshizo
    Department of Stomatognathic Function and Occlusal Reconstruction, Graduate School of Biomedical Sciences, Tokushima University
  • Yamamoto Yumiko
    Department of Bacteriology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
  • Raman Swarnalakshmi
    Department of Stomatognathic Function and Occlusal Reconstruction, Graduate School of Biomedical Sciences, Tokushima University
  • Ikutame Daisuke
    Department of Stomatognathic Function and Occlusal Reconstruction, Graduate School of Biomedical Sciences, Tokushima University
  • Iwasa Takuma
    Department of Stomatognathic Function and Occlusal Reconstruction, Graduate School of Biomedical Sciences, Tokushima University
  • Okura Kazuo
    Department of Stomatognathic Function and Occlusal Reconstruction, Graduate School of Biomedical Sciences, Tokushima University

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Other Title
  • 口腔顔面痛に対するボツリヌス毒素効果メカニズム

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Purpose: It has been reported that botulinum toxin is effective for myofascial pain, trigeminal neuropathic pain, migraine, etc. in the orofacial area. In this review, we describe basic research on the mechanism of botulinum toxin on trigeminal neuropathic pain. <br>Botulinum toxin effect mechanisms: We observed that peripheral intradermal administration of botulinum neurotoxin （BoNT） heavy chain 50kDa labeled with Alexa 488 reached sensory ganglia. Peripheral intradermal administration of botulinum toxin was also observed to attenuate peripheral neuropathic pain behavior and inhibited the release of FM4-64 in sensory ganglia. <br>Conclusion: Through peripheral intradermal administration, botulinum toxin could reach sensory ganglia after axonal transport and inhibit the release of neurotransmitters.

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