Advanced sebaceous carcinoma responsive to combination chemotherapy using carboplatin and paclitaxel : A case report

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  • AKANABE Honami
    Department of Dermatology, Nagoya University Graduate School of Medicine
  • MORI Shoichiro
    Department of Dermatology, Nagoya University Graduate School of Medicine Department of Dermatology, Toyohashi Municipal Hospital
  • HORISAKI Ken
    Department of Dermatology, Nagoya University Graduate School of Medicine
  • OHTA Mai
    Department of Dermatology, Nagoya University Graduate School of Medicine
  • IMAI Satoko
    Department of Dermatology, Nagoya University Graduate School of Medicine
  • AKIYAMA Masashi
    Department of Dermatology, Nagoya University Graduate School of Medicine

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Other Title
  • カルボプラチン・パクリタキセル療法が著効した進行期脂腺癌の1例

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<p>A 78－year－old woman noticed a nodule in the vicinity of her anus that gradually increased in size, in addition to subcutaneous nodules in the bilateral inguinal areas. Physical examination at the time of her first visit showed a yellowish mass (65×30 mm) accompanied by skin erosions near her anus, with enlarged bilateral inguinal lymph nodes. Computed tomography revealed multiple enlarged lymph nodes extending from the bilateral inguinal and left external iliac to the para－aortic region. A skin biopsy of the mass showed a mixture of tumor cells with atypical nuclei and foamy clear cytoplasm with sebaceous differentiation, and we diagnosed the patient with unresectable advanced sebaceous carcinoma. Combination chemotherapy using carboplatin and paclitaxel was initiated, and a partial response was achieved during the 15th course of treatment ; however, drug－induced eye injury necessitated treatment discontinuation. Combination chemotherapy using carboplatin and paclitaxel may be effective for treatment of unresectable advanced sebaceous carcinomas.[Skin Cancer (Japan) 2024 ; 39 : 36－40]</p>

Journal

  • Skin Cancer

    Skin Cancer 39 (1), 36-40, 2024

    The Japanese Skin Cancer Society

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